Protection of the intestinal mucosa by intraepithelial T cells
نویسندگان
چکیده
intraepithelial T lymphocytes (IEL) represent a major T cell population within the intestine of unclear functional relevance. The role of intestinal IEL was evaluated in the dextran sodium sulfate (DSS) induced mouse colitis model system. Large numbers of T cells, but not T cells, were localized at sites of DSS-induced epithelial cell damage. IEL in DSS treated mice expressed keratinocyte growth factor (KGF), a potent intestinal epithelial cell mitogen. cell-deficient mice (TCR / ) and KGFdeficient mice (KGF / ), but not cell-deficient mice (TCR / ), were more prone than wild-type mice to DSS-induced mucosal injury and demonstrated delayed tissue repair after termination of DSS treatment. Termination of DSS treatment resulted in vigorous epithelial cell proliferation in wild-type mice but not in TCR / mice or KGF / mice. These results suggest that IEL help preserve the integrity of damaged epithelial surfaces by providing the localized delivery of an epithelial cell growth factor.
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